CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.11340
Functional Family

Enzyme Information

2.4.1.221
Peptide-O-fucosyltransferase.
based on mapping to UniProt Q18014
Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.
-!- Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. -!- The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.

UniProtKB Entries (1)

Q18014
OFUT1_CAEEL
Caenorhabditis elegans
GDP-fucose protein O-fucosyltransferase 1

PDB Structure

PDB 3ZY5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights Into the Mechanism of Protein O-Fucosylation.
Lira-Navarrete, E., Valero-Gonzalez, J., Villanueva, R., Martinez-Julvez, M., Tejero, T., Merino, P., Panjikar, S., Hurtado-Guerrero, R.
Plos One