CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family DNA gyrase subunit B

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P9WG45
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P9WG45
GYRB_MYCTU
Mycobacterium tuberculosis H37Rv
DNA gyrase subunit B

PDB Structure

PDB 3ZKB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
Agrawal, A., Roue, M., Spitzfaden, C., Petrella, S., Aubry, A., Hann, M.M., Bax, B., Mayer, C.
Biochem.J.