CATH Classification

Domain Context

CATH Clusters

Superfamily Isoleucyl-tRNA Synthetase; Domain 1
Functional Family Leucine--tRNA ligase subunit beta

Enzyme Information

6.1.1.4
Leucine--tRNA ligase.
based on mapping to UniProt P07813
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

UniProtKB Entries (1)

P07813
SYL_ECOLI
Escherichia coli K-12
Leucine--tRNA ligase

PDB Structure

PDB 3ZJU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Hernandez, V., Crepin, T., Palencia, A., Cusack, S., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., O'Leary, A., Simon, N.L., De Marsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
Antimicrob.Agents Chemother.