CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1100
Functional Family Cystathionine beta-synthase

Enzyme Information

2.6.99.3
O-ureido-L-serine synthase.
based on mapping to UniProt D2Z027
O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate.
-!- The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. -!- Also catalyzes EC 2.5.1.47.
2.5.1.47
Cysteine synthase.
based on mapping to UniProt D2Z027
O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.
-!- Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors. -!- Not identical with EC 2.5.1.51, EC 2.5.1.52 and EC 2.5.1.53. -!- Formerly EC 4.2.99.8.

UniProtKB Entries (1)

D2Z027
DCSD_STRLA
Streptomyces lavendulae
O-ureido-L-serine synthase

PDB Structure

PDB 3X44
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structural and mutational analyses of O-ureido-L-serine synthase necessary for D-cycloserine biosynthesis
Uda, N., Matoba, Y., Oda, K., Kumagai, T., Sugiyama, M.
Febs J.