CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.150
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q8RQE9
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (2)

A7XX65
A7XX65_BP234
Thermus virus P23-45
Uncharacterized protein
Q8RQE9
RPOB_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit beta

PDB Structure

PDB 3WOE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K., Yokoyama, S.
Genes Dev.