CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Malic enzyme

Enzyme Information

1.1.1.40
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
based on mapping to UniProt P48163
(1) (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH. (2) Oxaloacetate = pyruvate + CO(2).
-!- The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39.

UniProtKB Entries (1)

P48163
MAOX_HUMAN
Homo sapiens
NADP-dependent malic enzyme

PDB Structure

PDB 3WJA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characteristics of the nonallosteric human cytosolic malic enzyme
Hsieh, J.Y., Li, S.-Y., Chen, M.-C., Yang, P.-C., Chen, H.-Y., Chan, N.-L., Liu, J.-H., Hung, H.-C.
Biochim.Biophys.Acta