CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P03587
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P03587
2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt P03587
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
2.1.1.-
Methyltransferases.
based on mapping to UniProt P03587

UniProtKB Entries (1)

P03587
RDRP_TOML
Tobacco mosaic virus strain tomato/L
Replicase large subunit

PDB Structure

PDB 3VKW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the superfamily 1 helicase from tomato mosaic virus
Nishikiori, M., Sugiyama, S., Xiang, H., Niiyama, M., Ishibashi, K., Inoue, T., Ishikawa, M., Matsumura, H., Katoh, E.
J.Virol.