CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.22
Stromelysin 2.
based on mapping to UniProt P09238
Similar to stromelysin 1, but action on collagen types III, IV and V is weak.
-!- Digests gelatin types I, III, IV, V, fibronectin and proteoglycan. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P09238
MMP10_HUMAN
Homo sapiens
Stromelysin-2

PDB Structure

PDB 3V96
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
Batra, J., Robinson, J., Soares, A.S., Fields, A.P., Radisky, D.C., Radisky, E.S.
J.Biol.Chem.