CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase beta, N-terminal domain-like
Functional Family DNA polymerase beta

Enzyme Information

4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt P06766
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P06766
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P06766
DPOLB_RAT
Rattus norvegicus
DNA polymerase beta

PDB Structure

PDB 3UXP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase beta.
Gridley, C.L., Rangarajan, S., Firbank, S., Dalal, S., Sweasy, J.B., Jaeger, J.
Biochemistry