CATH Classification

Domain Context

CATH Clusters

Superfamily Ankyrin repeat-containing domain
Functional Family Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.-
Pentosyltransferases.
based on mapping to UniProt Q9H2K2
2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q9H2K2
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q9H2K2
TNKS2_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase tankyrase-2

PDB Structure

PDB 3TWQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Guettler, S., Larose, J., Petsalaki, E., Gish, G., Scotter, A., Pawson, T., Rottapel, R., Sicheri, F.
Cell(Cambridge,Mass.)