CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Functional Family Anthranilate phosphoribosyltransferase

Enzyme Information

2.4.2.18
Anthranilate phosphoribosyltransferase.
based on mapping to UniProt P9WFX5
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

P9WFX5
TRPD_MYCTU
Mycobacterium tuberculosis H37Rv
Anthranilate phosphoribosyltransferase

PDB Structure

PDB 3TWP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Castell, A., Short, F.L., Evans, G.L., Cookson, T.V., Bulloch, E.M., Joseph, D.D., Lee, C.E., Parker, E.J., Baker, E.N., Lott, J.S.
Biochemistry