CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit alpha

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P27791
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

P27791
KAPCA_RAT
Rattus norvegicus
CAMP-dependent protein kinase catalytic subunit alpha
P31324
KAP3_MOUSE
Mus musculus
CAMP-dependent protein kinase type II-beta regulatory subunit

PDB Structure

PDB 3TNQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and allostery of the PKA RIIbeta tetrameric holoenzyme
Zhang, P., Smith-Nguyen, E.V., Keshwani, M.M., Deal, M.S., Kornev, A.P., Taylor, S.S.
Science