CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt O60674
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O60674
JAK2_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK2

PDB Structure

PDB 3TJC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors.
Schenkel, L.B., Huang, X., Cheng, A., Deak, H.L., Doherty, E., Emkey, R., Gu, Y., Gunaydin, H., Kim, J.L., Lee, J., Loberg, R., Olivieri, P., Pistillo, J., Tang, J., Wan, Q., Wang, H.L., Wang, S.W., Wells, M.C., Wu, B., Yu, V., Liu, L., Geuns-Meyer, S.
J.Med.Chem.