CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Probable ATP-dependent RNA helicase DDX58

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt Q6Q899
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q6Q899
DDX58_MOUSE
Mus musculus
Probable ATP-dependent RNA helicase DDX58

PDB Structure

PDB 3TBK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling.
Civril, F., Bennett, M., Moldt, M., Deimling, T., Witte, G., Schiesser, S., Carell, T., Hopfner, K.P.
Embo Rep.