CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Quinate/shikimate dehydrogenase

Enzyme Information

1.1.1.282
Quinate/shikimate dehydrogenase.
based on mapping to UniProt Q8ZPR4
(1) L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. (2) Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H.
-!- The enzyme is found in bacteria (mostly, but not exclusively, Gram- positive bacteria), fungi, and plants. -!- It participates in the degradation of quinate and shikimate with a strong preference for NAD+ as a cofactor. -!- While the enzyme can act on both quinate and shikimate, activity is higher with the former.

UniProtKB Entries (1)

Q8ZPR4
YDIB_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Quinate/shikimate dehydrogenase

PDB Structure

PDB 3T4E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
1.95 Angstrom Crystal Structure of Shikimate 5-dehydrogenase (AroE) from Salmonella enterica subsp. enterica serovar Typhimurium in Complex with NAD.
Minasov, G., Light, S.H., Halavaty, A., Shuvalova, L., Dubrovska, I., Winsor, J., Papazisi, L., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
TO BE PUBLISHED