CATH Classification

Domain Context

CATH Clusters

Superfamily PK beta-barrel domain-like
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt Q6GG09
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

Q6GG09
KPYK_STAAR
Staphylococcus aureus subsp. aureus MRSA252
Pyruvate kinase

PDB Structure

PDB 3T05
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.
Zoraghi, R., Worrall, L., See, R.H., Strangman, W., Popplewell, W.L., Gong, H., Samaai, T., Swayze, R.D., Kaur, S., Vuckovic, M., Finlay, B.B., Brunham, R.C., McMaster, W.R., Davies-Coleman, M.T., Strynadka, N.C., Andersen, R.J., Reiner, N.E.
J.Biol.Chem.