CATH Classification

Domain Context

CATH Clusters

Superfamily Neutral Protease Domain 2
Functional Family Thermolysin

Enzyme Information

3.4.24.27
Thermolysin.
based on mapping to UniProt P00800
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.

UniProtKB Entries (2)

P00800
THER_BACTH
Bacillus thermoproteolyticus
Thermolysin
P82176
IMPI_GALME
Galleria mellonella
Inducible metalloproteinase inhibitor protein

PDB Structure

PDB 3SSB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a Peptide bond.
Arolas, J.L., Botelho, T.O., Vilcinskas, A., Gomis-Ruth, F.X.
Angew.Chem.Int.Ed.Engl.