CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Venom plasminogen activator TSV-PA

Enzyme Information

3.4.21.95
Snake venom factor V activator.
based on mapping to UniProt P18965
Fully activates human clotting factor V by a single cleavage at the 1545- Trp-Tyr-Leu-Arg-|-Ser-Asn-Asn-Gly-1552 bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO(2).
-!- Inhibited by diisopropyl fluorophosphate. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P18965
VSPG_DABSI
Daboia siamensis
Factor V activator RVV-V gamma

PDB Structure

PDB 3S9A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of coagulation factor V recognition for cleavage by RVV-V
Nakayama, D., Ben Ammar, Y., Miyata, T., Takeda, S.
Febs Lett.