CATH Classification

Domain Context

CATH Clusters

Superfamily Tetratricopeptide repeat domain
Functional Family N-lysine methyltransferase SMYD2 isoform X2

Enzyme Information

2.1.1.-
Methyltransferases.
based on mapping to UniProt Q9NRG4
2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NRG4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9NRG4
SMYD2_HUMAN
Homo sapiens
N-lysine methyltransferase SMYD2

PDB Structure

PDB 3S7F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Substrate Methylation and Inhibition of SMYD2.
Ferguson, A.D., Larsen, N.A., Howard, T., Pollard, H., Green, I., Grande, C., Cheung, T., Garcia-Arenas, R., Cowen, S., Wu, J., Godin, R., Chen, H., Keen, N.
Structure