CATH Classification

Domain Context

CATH Clusters

Superfamily DNA ligase/mRNA capping enzyme
Functional Family mRNA-capping enzyme

Enzyme Information

2.7.7.50
mRNA guanylyltransferase.
based on mapping to UniProt O55236
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
-!- Can modify also synthetic poly(A) and poly(G) to form the structures m(7)G(5')pppAn and m(7)G(5')pppGn.
3.1.3.33
Polynucleotide 5'-phosphatase.
based on mapping to UniProt O55236
A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Does not act on nucleoside monophosphates. -!- Induced in Escherichia coli by T-even phages.

UniProtKB Entries (1)

O55236
MCE1_MOUSE
Mus musculus
MRNA-capping enzyme

PDB Structure

PDB 3RTX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights to how mammalian capping enzyme reads the CTD code.
Ghosh, A., Shuman, S., Lima, C.D.
Mol.Cell