CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase C15, pyroglutamyl peptidase I-like
Functional Family Pyrrolidone-carboxylate peptidase

Enzyme Information

3.4.19.3
Pyroglutamyl-peptidase I.
based on mapping to UniProt P46107
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
-!- Removes 5-oxoproline from various penultimate amino acid residues except L-proline. -!- Inhibited by thiol-blocking reagents. -!- Belongs to peptidase family C15. -!- Formerly EC 3.4.11.8.

UniProtKB Entries (1)

P46107
PCP_BACAM
Bacillus amyloliquefaciens
Pyrrolidone-carboxylate peptidase

PDB Structure

PDB 3RO0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Terpyridine platinum(II) complexes inhibit cysteine proteases by binding to active-site cysteine.
Lo, Y.-C., Su, W.-C., Ko, T.-P., Wang, N.-C., Wang, A.H.-J.
J.Biomol.Struct.Dyn.