CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 2-isopropylmalate synthase

Enzyme Information

2.3.3.13
2-isopropylmalate synthase.
based on mapping to UniProt Q9JZG1
Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA.
-!- Formerly EC 4.1.3.12.

UniProtKB Entries (1)

Q9JZG1
LEU1_NEIMB
Neisseria meningitidis MC58
2-isopropylmalate synthase

PDB Structure

PDB 3RMJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Huisman, F.H.A., Koon, N., Bulloch, E.M.M., Baker, H.M., Baker, E.N., Squire, C.J., Parker, E.J.
Biochemistry