CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Alcohol dehydrogenase

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P10807
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P10807
ADH_DROLE
Scaptodrosophila lebanonensis
Alcohol dehydrogenase

PDB Structure

PDB 3RJ5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity.
Wuxiuer, Y., Morgunova, E., Cols, N., Popov, A., Karshikoff, A., Sylte, I., Gonzalez-Duarte, R., Ladenstein, R., Winberg, J.O.
Febs J.