CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1970
Functional Family

Enzyme Information

4.1.1.21
Phosphoribosylaminoimidazole carboxylase.
based on mapping to UniProt Q73PV9
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1- (5-phospho-D-ribosyl)imidazole + CO(2).
-!- While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18. -!- 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.

UniProtKB Entries (1)

Q73PV9
PURE_TREDE
Treponema denticola ATCC 35405
Phosphoribosylaminoimidazole carboxylase

PDB Structure

PDB 3RGG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Treponema denticola PurE Is a Bacterial AIR Carboxylase.
Tranchimand, S., Starks, C.M., Mathews, I.I., Hockings, S.C., Kappock, T.J.
Biochemistry