CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.1.21
Thymidine kinase.
based on mapping to UniProt P03176
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

P03176
KITH_HHV11
Human alphaherpesvirus 1 strain 17
Thymidine kinase

PDB Structure

PDB 3RDP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.
Martic, M., Pernot, L., Westermaier, Y., Perozzo, R., Kraljevic, T.G., Kristafor, S., Raic-Malic, S., Scapozza, L., Ametamey, S.
Nucleosides Nucleotides Nucleic Acids