CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoglycerate mutase-like
Functional Family 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2

Enzyme Information

3.1.3.46
Fructose-2,6-bisphosphate 2-phosphatase.
based on mapping to UniProt Q16875
Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
-!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).
2.7.1.105
6-phosphofructo-2-kinase.
based on mapping to UniProt Q16875
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
-!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.

UniProtKB Entries (1)

Q16875
F263_HUMAN
Homo sapiens
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

PDB Structure

PDB 3QPU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: Transition state and the C-terminal function.
Cavalier, M.C., Kim, S.G., Neau, D., Lee, Y.H.
Proteins