CATH Classification

Domain Context

CATH Clusters

Superfamily Amidase signature (AS) domain
Functional Family Fatty-acid amide hydrolase 1

Enzyme Information

3.5.1.99
Fatty acid amide hydrolase.
based on mapping to UniProt P97612
(1) Anandamide + H(2)O = arachidonic acid + ethanolamine. (2) Oleamide + H(2)O = oleic acid + NH(3).
-!- Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia. -!- Formerly EC 3.5.1.n2.

UniProtKB Entries (1)

P97612
FAAH1_RAT
Rattus norvegicus
Fatty-acid amide hydrolase 1

PDB Structure

PDB 3QJ9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Min, X., Thibault, S.T., Porter, A.C., Gustin, D.J., Carlson, T.J., Xu, H., Lindstrom, M., Xu, G., Uyeda, C., Ma, Z., Li, Y., Kayser, F., Walker, N.P., Wang, Z.
Proc.Natl.Acad.Sci.USA