CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

5.3.99.10
Thiazole tautomerase.
based on mapping to UniProt P25053
2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate.
-!- The enzyme catalyzes the irreversible aromatization of the thiazole moiety of 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate.

UniProtKB Entries (1)

P25053
TENI_BACSU
Bacillus subtilis subsp. subtilis str. 168
Thiazole tautomerase

PDB Structure

PDB 3QH2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase.
Hazra, A.B., Han, Y., Chatterjee, A., Zhang, Y., Lai, R.Y., Ealick, S.E., Begley, T.P.
J.Am.Chem.Soc.