CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Eukaryotic translation initiation factor 2-alpha kinase 3

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9Z2B5
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9Z2B5
E2AK3_MOUSE
Mus musculus
Eukaryotic translation initiation factor 2-alpha kinase 3

PDB Structure

PDB 3QD2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of the PERK kinase domain suggests the mechanism for its activation.
Cui, W., Li, J., Ron, D., Sha, B.
Acta Crystallogr.,Sect.D