CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase A1

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P08263
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
1.11.1.-
Peroxidases.
based on mapping to UniProt P08263
5.3.3.-
Transposing C=C bonds.
based on mapping to UniProt P08263

UniProtKB Entries (1)

P08263
GSTA1_HUMAN
Homo sapiens
Glutathione S-transferase A1

PDB Structure

PDB 3Q74
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure Analysis of the L7A Mutant of the Apo Form of Human Alpha Class Glutathione Transferase
Khoza, T.N., Fanucchi, S., Achilonu, I.A., Fernandes, M.A., Dirr, H.W.
To be Published