CATH Classification

Domain Context

CATH Clusters

Superfamily GHMP kinase, C-terminal domain
Functional Family 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Enzyme Information

2.7.1.148
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
based on mapping to UniProt P9WKG7
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P9WKG7
ISPE_MYCTU
Mycobacterium tuberculosis H37Rv
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

PDB Structure

PDB 3PYG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structural Basis for anti-TB Drug Discovery targeting of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis
Shan, S., Chen, X.H., Liu, T., Zhao, H.C., Rao, Z.H., Lou, Z.Y.
To be Published