CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P12259
FA5_HUMAN
Homo sapiens
Coagulation factor V

PDB Structure

PDB 3P6Z
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.
Corral-Rodriguez, M.A., Bock, P.E., Hernandez-Carvajal, E., Gutierrez-Gallego, R., Fuentes-Prior, P.
Blood