CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Erythronate-4-phosphate dehydrogenase

Enzyme Information

1.1.1.290
4-phosphoerythronate dehydrogenase.
based on mapping to UniProt P60802
4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH.
-!- This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. -!- The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+). -!- In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid. -!- Cf. EC 1.1.1.399.

UniProtKB Entries (1)

P60802
PDXB_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Erythronate-4-phosphate dehydrogenase

PDB Structure

PDB 3OET
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
D-Erythronate-4-Phosphate Dehydrogenase complexed with NAD
Filippova, E.V., Wawrzak, Z., Onopriyenko, O., Savchenko, A., Edwards, A., Anderson, W.F.
To be Published