CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome c-like domain
Functional Family L-cysteine S-thiosulfotransferase subunit SoxA

Enzyme Information

2.8.5.2
L-cysteine S-thiosulfotransferase.
based on mapping to UniProt D7A6E5
(1) [SoxY protein]-L-cysteine + thiosulfate + 2 ferricytochrome c = [SoxY protein]-S-sulfosulfanyl-L-cysteine + 2 ferrocytochrome c + 2 H(+). (2) [SoxY protein]-S-sulfanyl-L-cysteine + thiosulfate + 2 ferricytochrome c = [SoxY protein]-S-(2-sulfodisulfanyl)-L-cysteine + 2 ferrocytochrome c + 2 H(+).
-!- The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. -!- It catalyzes two reactions in the pathway - early in the pathway it attaches a thiosulfate molecule to the sulfur atom of an L-cysteine of a SoxY protein; later it transfers a second thiosulfate molecule to a sulfane group that is already attached to the same cysteine residue.

UniProtKB Entries (2)

D7A6E5
SOXA_STAND
Starkeya novella DSM 506
L-cysteine S-thiosulfotransferase subunit SoxA
Q7BQR5
Q7BQR5_STANO
Starkeya novella
SoxX

PDB Structure

PDB 3OA8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Diheme SoxAX proteins - insights into structure and function of the active site
Kilmartin, J., Maher, M.J., Krusong, K., Hanson, G.R., Bernhardt, P.V., Riley, M., Kappler, U.
To be Published