CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P29597
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29597
TYK2_HUMAN
Homo sapiens
Non-receptor tyrosine-protein kinase TYK2

PDB Structure

PDB 3NZ0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A new regulatory switch in a JAK protein kinase.
Tsui, V., Gibbons, P., Ultsch, M., Mortara, K., Chang, C., Blair, W., Pulk, R., Stanley, M., Starovasnik, M., Williams, D., Lamers, M., Leonard, P., Magnuson, S., Liang, J., Eigenbrot, C.
Proteins