CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family G protein-coupled receptor kinase

Enzyme Information

2.7.11.16
[G-protein-coupled receptor] kinase.
based on mapping to UniProt P43250
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
-!- All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. -!- (cf. EC 2.7.11.14 and EC 2.7.11.15).

UniProtKB Entries (1)

P43250
GRK6_HUMAN
Homo sapiens
G protein-coupled receptor kinase 6

PDB Structure

PDB 3NYO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis for activation of G protein-coupled receptor kinases.
Boguth, C.A., Singh, P., Huang, C.C., Tesmer, J.J.
Embo J.