CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Catechol O-methyltransferase

Enzyme Information

2.1.1.6
Catechol O-methyltransferase.
based on mapping to UniProt P22734
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
-!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

UniProtKB Entries (1)

P22734
COMT_RAT
Rattus norvegicus
Catechol O-methyltransferase

PDB Structure

PDB 3NW9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Recognition at the Active Site of Catechol-O-methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors
Ellermann, M., Paulini, R., Jakob-Roetne, R., Lerner, C., Borroni, E., Roth, D., Ehler, A., Schweizer, W.B., Schlatter, D., Rudolph, M.G., Diederich, F.
Chemistry