CATH Classification
Domain Context
CATH Clusters
| Superfamily | Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A |
| Functional Family | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
Enzyme Information
| 2.7.7.60 |
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
based on mapping to UniProt Q46893
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
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UniProtKB Entries (1)
| Q46893 |
ISPD_ECOLI
Escherichia coli K-12
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
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PDB Structure
| PDB | 3N9W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Experimental and computational active site mapping as a starting point to fragment-based lead discovery.
Chemmedchem
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