CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Homocitrate synthase, mitochondrial

Enzyme Information

2.3.3.14
Homocitrate synthase.
based on mapping to UniProt Q9Y823
Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2-hydroxybutane-1,2,4- tricarboxylate + CoA.
-!- Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36. -!- Also acts with oxaloacetate as substrate, but more slowly. -!- Formerly EC 4.1.3.21.

UniProtKB Entries (1)

Q9Y823
HOSM_SCHPO
Schizosaccharomyces pombe 972h-
Homocitrate synthase, mitochondrial

PDB Structure

PDB 3MI3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase
Bulfer, S.L., Scott, E.M., Pillus, L., Trievel, R.C.
J.Biol.Chem.