CATH Classification

Domain Context

CATH Clusters

Superfamily Bira Bifunctional Protein; Domain 2
Functional Family

Enzyme Information

6.2.1.n2
Amino acid--[acyl-carrier-protein] ligase.
based on mapping to UniProt Q89VT8
ATP + an amino acid + [acyl-carrier-protein] = AMP + diphosphate + an aminoacyl-[acyl-carrier-protein].
-!- Catalyzes the ATP-dependent activation of L-alanine, and to a lesser extent of L-glycine and L-serine, and their transfer to the phosphopantetheine prosthetic group covalently attached to a vicinal carrier protein. -!- May participate in nonribosomal peptide synthesis or related processes. -!- L-proline and L-glutamate are very poor substrates whereas D-amino acids are not substrates for ATP-dependent activation. -!- Does not display tRNA aminoacylation activity.

UniProtKB Entries (1)

Q89VT8
AACL1_BRADU
Bradyrhizobium diazoefficiens USDA 110
Amino acid--[acyl-carrier-protein] ligase 1

PDB Structure

PDB 3MF2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis
Mocibob, M., Ivic, N., Bilokapic, S., Maier, T., Luic, M., Ban, N., Weygand-Durasevic, I.
Proc.Natl.Acad.Sci.USA