CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Isoprene synthase, chloroplastic

Enzyme Information

4.2.3.61
5-epiaristolochene synthase.
based on mapping to UniProt Q40577
(2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate.
-!- Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.

UniProtKB Entries (1)

Q40577
5EAS_TOBAC
Nicotiana tabacum
5-epi-aristolochene synthase

PDB Structure

PDB 3M02
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates.
Noel, J.P., Dellas, N., Faraldos, J.A., Zhao, M., Hess, B.A., Smentek, L., Coates, R.M., O'Maille, P.E.
Acs Chem.Biol.