CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Protein-glutamine gamma-glutamyltransferase 2

Enzyme Information

2.3.2.13
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt P21980
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

P21980
TGM2_HUMAN
Homo sapiens
Protein-glutamine gamma-glutamyltransferase 2

PDB Structure

PDB 3LY6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human transglutaminase 2 in complex with adenosine triphosphate
Han, B.G., Cho, J.W., Cho, Y.D., Jeong, K.C., Kim, S.Y., Lee, B.I.
Int.J.Biol.Macromol.