CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Pyruvate dehydrogenase E1 component

Enzyme Information

1.2.4.1
Pyruvate dehydrogenase (acetyl-transferring).
based on mapping to UniProt P0AFG9
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
-!- It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4. -!- It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

UniProtKB Entries (1)

P0AFG9
ODP1_ECO57
Escherichia coli O157:H7
Pyruvate dehydrogenase E1 component

PDB Structure

PDB 3LPL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms.
Nemeria, N.S., Arjunan, P., Chandrasekhar, K., Mossad, M., Tittmann, K., Furey, W., Jordan, F.
J.Biol.Chem.