CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family DNA polymerase beta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P06746
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt P06746

UniProtKB Entries (1)

P06746
DPOLB_HUMAN
Homo sapiens
DNA polymerase beta

PDB Structure

PDB 3LK9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid.
Surya Prakash, G.K., Zibinsky, M., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertell, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Shock, D.D., Wilson, S.H., Olah, G.A.
Proc.Natl.Acad.Sci.USA