CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.65
Macrophage elastase.
based on mapping to UniProt P39900
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P39900
MMP12_HUMAN
Homo sapiens
Macrophage metalloelastase

PDB Structure

PDB 3LIR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
Devel, L., Garcia, S., Czarny, B., Beau, F., LaJeunesse, E., Vera, L., Georgiadis, D., Stura, E., Dive, V.
J.Biol.Chem.