CATH Classification

Domain Context

CATH Clusters

Superfamily PCRA; domain 4
Functional Family DNA helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P03018
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P03018
UVRD_ECOLI
Escherichia coli K-12
DNA helicase II

PDB Structure

PDB 3LFU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Rotations of the 2B sub-domain of E. coli UvrD helicase/translocase coupled to nucleotide and DNA binding.
Jia, H., Korolev, S., Niedziela-Majka, A., Maluf, N.K., Gauss, G.H., Myong, S., Ha, T., Waksman, G., Lohman, T.M.
J.Mol.Biol.