CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.179 |
16S rRNA (guanine(1405)-N(7))-methyltransferase.
based on mapping to UniProt Q7M0R2
S-adenosyl-L-methionine + guanine(1405) in 16S rRNA = S-adenosyl-L- homocysteine + N(7)-methylguanine(1405) in 16S rRNA.
-!- The enzyme from the antibiotic-producing bacterium Micromonospora zionensis specifically methylates guanine(1405) at N(7) in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins.
|
UniProtKB Entries (1)
| Q7M0R2 |
SGM_MICZI
Micromonospora zionensis
16S rRNA (guanine(1405)-N(7))-methyltransferase
|
PDB Structure
| PDB | 3LCU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases.
Nucleic Acids Res.
|