CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14965
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965
AURKA_HUMAN
Homo sapiens
Aurora kinase A

PDB Structure

PDB 3LAU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Lesuisse, D., Dutruc-Rosset, G., Tiraboschi, G., Dreyer, M.K., Maignan, S., Chevalier, A., Halley, F., Bertrand, P., Burgevin, M.C., Quarteronet, D., Rooney, T.
Bioorg.Med.Chem.Lett.