CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor Tie-1

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q02763
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q02763
TIE2_HUMAN
Homo sapiens
Angiopoietin-1 receptor

PDB Structure

PDB 3L8P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
Fedorov, A.A., Fedorov, E.V., Pauletti, D., Meyer, S.L., Hudkins, R.L., Almo, S.C.
To be Published