CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt P80244
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

P80244
CLPP_BACSU
Bacillus subtilis subsp. subtilis str. 168
ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB 3KTK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
Lee, B.-G., Park, E.Y., Lee, K.-E., Jeon, H., Sung, K.H., Paulsen, H., Rubsamen-Schaeff, H., Brotz-Oesterhelt, H., Song, H.K.
Nat.Struct.Mol.Biol.